Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation
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چکیده
منابع مشابه
Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1.
Although potential contribution of endothelial progenitor cells (EPCs) to angiogenesis in glioma has been proposed, the molecular mechanisms of EPCs recruitment to vasculature have not been fully elucidated. Here, we show that the supernatant from glioma cells promotes EPCs angiogenesis via VEGFR-2, not VEGFR-1. Moreover, VEGFR-2 siRNA inhibits VEGFR-2 expression in EPCs, tube formation on matr...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2004
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207712